Alpinia galanga is a commonly used ingredient in Asian food and traditional medicine. But an extract of the rhizome was never used commercially in food supplements and functional foods. There is some evidence of safety and tolerability in humans for a proprietary A. galanga rhizome extract (EnXtra™). It is Generally Recognised as Safe (GRAS) in the US already. The study was conducted using Sprague Dawley rats that were orally administered the test item for 90 days by following OECD (Test Guideline: 408), with a recovery period of 48 days. This showed that on terminal sacrifice, no treatment-related adverse effects were observed.