Protein is crucial for muscle strength but typically requires weeks to show effects. This study evaluated botanical extracts for enhancing and accelerating muscle development. Twenty-six participants were randomized into five arms: EB-MS-01 (300 mg Microcrystalline cellulose (MCC) without exercise), EB-MS-02 (300 mg MCC with exercise), EB-MS-03 (500 mg Phyllanthus amarus with exercise), EB-MS-04 (250 mg Cinnamomum verum with exercise), and EB-MS-05 (350 mg Ocimum sanctum + Rosmarinus officinalis with exercise). Participants consumed two Investigational Products (IP) capsules before breakfast, and 24 gm whey protein (WP) with breakfast and dinner. IP intake ceased for responders with a ≥10% increase in muscle strength, as assessed by 1-repetition maximum (1-RM) at day 28, while the remaining participants continued the study until day 56. Outcomes included changes in muscle strength, body composition via DEXA, thigh muscle girth, fatigue using VAS-Fatigue scale, and sleep quality by modified Insomnia Severity Index. Safety was monitored for digestive system adverse effects. At end of the study, EB-MS-03 group showed a 13.05% increase in 1-RM, whereas those in the EB-MS-02, EB-MS-04 and EB-MS-05 groups experienced an increase of 9.65%, 12.78%, and 9.39%, respectively. EB-MS-03 group showed a meaningful decrease in body fat, visceral fat, android fat and an increase in lean body mass. No serious adverse events were reported, though some participants experienced mild digestive discomfort unrelated to IP. The proof-of-concept study concluded that EB-MS-03 with WP, increased muscle strength compared to WP alone. Future studies will involve a larger sample size and longer duration for more comprehensive results.

Cardiac health is a determinant of athletic performance. Typically endurance products test for VO2 max but only a few investigate the underlying mechanism of such improvement in total aerobic capacity. Vedic Lifesciences planned a trial for a Terminalia arjuna (TA) extract “Oxyjun” to study specifically the cardiac component of VO2 max by measuring the left ventricular ejection fraction (LVEF) in healthy young adults using 2D-echocardiography. Thirty-two healthy males, aged 18–40 years performing regular endurance exercise, were randomly assigned to the extract or placebo. Fifty-six days of Oxyjun supplementation significantly improved LVEF and decreased myocardial performance index. Oxyjun reduced fatigue as assessed by Borg’s rated perceived exertion scale. There was no significant change in creatine kinase-MB and troponin-T indicating no cardiac damage. Oxyjun significantly increased cardiovascular efficiency and improved cardiac conditioning in young healthy adults.