The study was conducted to assess the effect of IP in subjects with osteoarthritis with mild to moderate pain. The effect of the treatment on rescue medication consumption which is directly proportional to the degree of pain was also be captured via this study. the efficacy parameters such as effect on various joint health parameters (pain, stiffness and physical activity) were studied by using the WOMAC scale. The individuals with knee OA suffer from an increased impact on their activities of daily living, leading also to an important decrease in their quality of life. Thus, an important outcome to be evaluated in this study is the quality of life of these individuals which was also assessed. One of the aims of this study is therefore to investigate the levels of different dimensions of fatigue in knee OA and to assess changes in fatigue after the treatment targeting pain reduction and physical functioning.