A RCT, placebo-controlled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heattreated Bifidobacterium longum CECT 7347 (HT- ES1) in participants with diarrhea-predominant irritable bowel syndrome
This trial determines the efficacy of the probiotic Bifidobacterium longum CECT 7347 (ES1) and postbioticheat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in improving symptom severity in adultswith diarrhea-predominant irritable bowel syndrome (IBS-D). Two capsules of eitherES1, HT-ES1 or placebo were administered orally, once daily, for 84 days (12 weeks). The primaryoutcome was change in total IBS-Symptom […]