This Nutrition Research Project is the clinical development of a popular food supplement, 5-ALA+SFC as an immune system enhancer for the COVID-19 vaccine. While the end of the pandemic is unclear, COVID-19 vaccine efficacy has been questioned in recent times. Hence our research attains public health significance if vaccine efficacy can be improved through an approved food supplement. 5-ALA is widely present in our diet and is a well-studied essential amino acid. Initial results have shown that 5-ALA+SFC may improve IgG titers against the SARS-CoV2 antigen, and is well-tolerated. Larger studies are needed for this project of global significance.